Zepbound is a medication designed to help with weight loss and manage conditions like obesity.
It’s effective but can come with side effects, including digestive issues. One concern for some users is constipation.
This article explains why Zepbound can cause constipation, how to manage it, and what to expect.
What Is Zepbound and How Does It Work?
Zepbound, with the active ingredient tirzepatide, is a weekly injectable drug. It mimics two hormones, GLP-1 and GIP, which control appetite and digestion. These hormones slow stomach emptying and increase insulin release. This helps with weight loss but can affect bowel movements.
Zepbound is FDA-approved for adults with obesity or those overweight with conditions like type 2 diabetes or high blood pressure. It’s also used for obstructive sleep apnea in obese adults. The medication promotes fullness, reducing food intake. However, its effect on digestion can lead to side effects like constipation.
Related: Can I Take Zepbound After Gallbladder Removal?
Common Side Effects of Zepbound
Zepbound commonly causes digestive issues, especially when starting treatment or increasing doses. Nausea, diarrhea, and vomiting are the most frequent side effects. Constipation is also reported, though less common than nausea. These effects often improve as the body adjusts.
Clinical trials show constipation in up to 17% of Zepbound users. Other side effects include stomach pain, bloating, and injection site reactions. Most are mild and temporary. Severe or persistent symptoms should be discussed with a doctor.
Why Zepbound Can Cause Constipation
Zepbound can cause constipation because it slows gastric emptying. Food moves more slowly through the stomach and intestines, leading to harder, less frequent stools. This delayed digestion is part of how Zepbound reduces appetite. However, it can disrupt normal bowel patterns.
Dehydration can worsen constipation. Zepbound’s side effects, like nausea or vomiting, may reduce fluid intake. Reduced appetite can also lead to less fiber consumption. These factors combine to make constipation a notable issue for some users.
How Common Is Constipation with Zepbound?
Clinical trials, like SURMOUNT-4, report constipation in about 20.7% of users during the first 36 weeks. This is more common at higher doses, like 10 mg or 15 mg. Constipation is typically mild to moderate. It often decreases over time as the body adapts.
User reviews reflect similar experiences. About 15.9% of 422 Zepbound users on Drugs.com mentioned constipation. Most cases are manageable with lifestyle changes. Persistent issues may require medical advice.
Who Is at Risk for Constipation?
Certain factors increase the likelihood of constipation with Zepbound. Higher doses (10 mg or 15 mg) are linked to more frequent symptoms. Women and older adults may be more prone to digestive side effects. Those with a history of constipation are also at higher risk.
Lifestyle plays a role too. A low-fiber diet or inadequate hydration can worsen symptoms. Sedentary habits may further slow digestion. Understanding these risks helps in preventing and managing constipation.
Symptoms of Constipation to Monitor
Constipation involves infrequent or difficult bowel movements. You may have fewer than three bowel movements per week. Stools may be hard, dry, or painful to pass. Bloating or abdominal discomfort often accompanies these symptoms.
With Zepbound, constipation may occur alongside nausea or stomach pain. Severe cases can cause significant discomfort or a feeling of fullness. If symptoms persist or worsen, medical attention is necessary.
Managing Constipation from Zepbound
Constipation from Zepbound is often manageable with simple changes. These strategies can ease symptoms and improve comfort. Most are safe and easy to implement. Always consult your doctor before trying new remedies.
Increase Hydration
Drinking enough water is essential. Zepbound’s side effects, like nausea, can lead to dehydration. Men should aim for 3.7 liters daily, women for 2.7 liters. Proper hydration softens stools and supports regular bowel movements.
Add More Fiber
Fiber promotes easier bowel movements by adding bulk to stools. Include fruits, vegetables, whole grains, and legumes in your diet. Aim for 25–30 grams of fiber daily. Increase fiber gradually to avoid bloating or gas.
Stay Physically Active
Exercise stimulates digestion and bowel movements. Activities like walking, jogging, or yoga can help. Aim for 150 minutes of moderate activity per week. Even light movement can reduce constipation risk.
Consider Over-the-Counter Options
For ongoing constipation, over-the-counter remedies may help. Stool softeners like Colace or laxatives like Miralax are commonly used. Check with your doctor before starting these. They can recommend the safest options for you.
Foods to Avoid on Zepbound
Certain foods can worsen constipation or other Zepbound side effects. Avoiding these supports better digestion and comfort. A balanced diet also enhances the medication’s effectiveness.
- High-Fat Foods: Fried foods, butter, and cheese can slow digestion further.
- Processed Carbohydrates: White bread and sugary snacks lack fiber and may spike blood sugar.
- Carbonated Drinks: Sodas or sparkling water can increase bloating and gas.
Opt for whole foods like lean proteins, vegetables, and healthy fats. These support weight loss and digestion. Small, frequent meals can also reduce nausea and constipation.
Comparison of Zepbound Side Effects
The table below compares the frequency of common Zepbound side effects based on clinical trials. This helps put constipation in context with other digestive issues.
| Side Effect | Frequency | Notes |
|---|---|---|
| Nausea | 25–36% | Most common, often fades in weeks |
| Diarrhea | 19–21% | May cause dehydration, worsening constipation |
| Constipation | 16–20.7% | Common at higher doses, usually mild |
| Vomiting | 13–16% | Often occurs with nausea |
Constipation is less frequent than nausea but still significant. It’s often manageable with lifestyle adjustments.
When to Seek Medical Advice
Mild constipation usually improves with diet and hydration changes. However, severe or prolonged symptoms need attention. Contact your doctor if constipation lasts over a few weeks. Severe abdominal pain or blood in stools requires immediate care.
Zepbound can rarely cause serious issues like pancreatitis or gallbladder problems. Symptoms like intense stomach pain or persistent vomiting need urgent evaluation. Your doctor may adjust your dose or suggest alternative treatments.
Serious Side Effects of Zepbound
Beyond constipation, Zepbound has rare but serious side effects. These include pancreatitis, kidney issues, and allergic reactions. It carries a boxed warning for thyroid tumors based on animal studies. The human risk is unclear but monitored closely.
Symptoms like swelling, trouble breathing, or severe stomach pain require immediate attention. Regular check-ups help detect issues early. Always report unusual symptoms to your healthcare provider.
Preventing Constipation Before Starting Zepbound
Starting Zepbound with a plan can reduce constipation risk. Adopt a high-fiber diet before your first dose. Stay hydrated and maintain regular exercise. These habits support digestion and ease medication adjustment.
Discuss your digestive health history with your doctor. If you’ve had constipation before, they may suggest preventive measures. A gradual dose increase can also help your body adapt.
How Long Does Constipation Last?
Constipation from Zepbound often occurs in the first few months. It’s most common during dose increases or early treatment. Symptoms typically improve as your body adjusts. Studies suggest relief within 6–10 weeks for similar medications.
If constipation persists beyond a few months, consult your doctor. They may recommend treatments or evaluate if Zepbound is suitable. Never stop the medication without medical guidance.
Zepbound Compared to Other Weight Loss Drugs
Zepbound’s side effects are similar to other GLP-1 drugs like Wegovy or Mounjaro. Constipation rates are comparable, with Wegovy reporting 14.6% and Mounjaro 6–7%. Zepbound’s dual GLP-1/GIP action may increase digestive side effects slightly. Your doctor can help choose the best option.
Combining Zepbound with other medications, like insulin, may worsen side effects. Discuss all medications with your doctor. They can tailor your treatment to minimize risks.
Real-World Experiences with Zepbound
User reviews on platforms like Drugs.com show constipation as a common issue. Out of 422 reviews, 15.9% mentioned constipation, often mild. Many users manage it with hydration, fiber, or laxatives like Miralax. Some report improved symptoms over time.
Social media posts echo these findings. Users on X note constipation but find relief with lifestyle changes. Combining Zepbound with a healthy diet and exercise helps reduce symptoms for many.
Summary
Zepbound can cause constipation in about 16–20.7% of users, especially at higher doses.
This is due to slowed digestion and reduced fluid or fiber intake. Women, older adults, and those with prior constipation are at higher risk. Lifestyle changes like hydration, fiber, and exercise can help.
Severe or persistent symptoms need medical attention. With proper management, Zepbound can be used effectively for weight loss.
FAQ
Does Zepbound cause constipation in all users?
No, constipation affects about 16–20.7% of Zepbound users. It’s less common than nausea or diarrhea. Risk depends on dose, lifestyle, and individual factors.
How can I manage constipation from Zepbound?
Drink plenty of water, eat high-fiber foods, and stay active. Over-the-counter options like Miralax can help. Consult your doctor for personalized recommendations.
How long does Zepbound-related constipation last?
Constipation often lasts a few weeks, especially early in treatment. It typically improves within 6–10 weeks. Persistent issues should be discussed with your doctor.
Can diet prevent constipation on Zepbound?
Yes, a high-fiber diet with fruits, vegetables, and whole grains helps. Avoid high-fat or processed foods. Staying hydrated supports healthy digestion.
When should I contact my doctor about constipation?
Seek medical advice if constipation lasts over a few weeks or causes severe pain. Blood in stools or intense discomfort needs immediate attention. Your doctor may adjust your treatment.