Zepbound, a medication with tirzepatide, is a breakthrough for weight loss and now sleep apnea treatment. Approved by the FDA in December 2024 for obstructive sleep apnea (OSA), it offers hope for millions. Many wonder, does Medicare cover Zepbound for sleep apnea? Understanding coverage is key to accessing this costly drug.
OSA affects breathing during sleep, often linked to obesity. Zepbound helps by reducing weight and improving airway function. Medicare coverage for this new use is a game-changer for eligible patients. However, navigating the rules can be tricky.
This article explains Medicare’s coverage for Zepbound when used for sleep apnea. It covers eligibility, costs, and steps to ensure coverage. Let’s dive into how you can benefit from this treatment with Medicare.
Understanding Zepbound and Sleep Apnea
Zepbound works by mimicking GIP and GLP-1 hormones. These slow digestion and reduce appetite, aiding weight loss. This helps relieve OSA symptoms in adults with obesity.
The FDA approved Zepbound for moderate to severe OSA in December 2024. Clinical trials showed it reduced breathing interruptions by 25–29 per hour. It also led to 18–20% weight loss over a year.
OSA causes airway blockages, leading to paused breathing during sleep. This can cause fatigue and heart issues. Zepbound’s ability to address obesity makes it a unique treatment option.
Medicare Coverage for Zepbound
Does Medicare cover Zepbound for sleep apnea? Yes, Medicare Part D and some Medicare Advantage (Part C) plans can cover it. This applies when a doctor prescribes it for OSA, not weight loss.
Medicare does not cover Zepbound for weight loss alone due to current laws. The Centers for Medicare & Medicaid Services (CMS) confirmed coverage for OSA in January 2025. Coverage depends on your plan’s formulary.
Check your Part D plan’s drug list to confirm Zepbound is included. Some plans may require prior authorization to ensure it’s prescribed for OSA. Always verify with your insurer.
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Eligibility for Coverage
To qualify for Medicare coverage, you need a diagnosis of moderate to severe OSA. A sleep study confirming OSA (ICD-10 code G47.33) is often required. Your doctor must prescribe Zepbound for this condition.
You must be enrolled in a Medicare Part D plan or a Medicare Advantage plan with drug coverage. Obesity (BMI of 30 or higher) or being overweight (BMI of 27 or higher) with OSA is typically needed.
Some plans may ask for proof of other treatments, like CPAP use. Check your plan’s requirements to ensure eligibility. Your doctor can help provide necessary documentation.
Costs and Out-of-Pocket Expenses
Zepbound costs about $1,000–$1,500 per month without coverage. With Medicare Part D, out-of-pocket costs vary by plan. Copays can range from $25 to $600 monthly, depending on the formulary tier.
In 2025, Medicare Part D plans have a $590 maximum deductible. Out-of-pocket costs for covered drugs are capped at $2,000 per year. This cap helps limit expenses for Zepbound users.
Some plans may have high copays for Zepbound, as it’s often a high-tier drug. Contact your insurer to estimate costs. Compounded tirzepatide may be a cheaper alternative if coverage is denied.
Steps to Get Zepbound Covered
To ensure Medicare covers Zepbound for sleep apnea, follow these steps:
- Get a Diagnosis: Confirm moderate to severe OSA with a sleep study.
- Doctor’s Prescription: Ensure your doctor prescribes Zepbound for OSA, not weight loss.
- Check Formulary: Verify Zepbound is on your Part D plan’s drug list.
- Prior Authorization: Submit any required forms or proof of other treatments.
Your doctor’s office can help with paperwork. If coverage is denied, you can appeal with supporting evidence like sleep study results.
Sample Plan for Using Zepbound with Medicare
A clear plan helps you use Zepbound effectively while ensuring coverage. Below is a sample weekly schedule for managing OSA treatment. Adjust it to fit your needs.
| Day | Activity | Notes |
|---|---|---|
| Monday | Take Zepbound shot, eat balanced breakfast | Inject at 8 AM, have oatmeal with fruit |
| Tuesday | Use CPAP, stay hydrated | Drink 8 cups water, monitor symptoms |
| Wednesday | Follow-up with doctor, light exercise | Discuss side effects, 20-minute walk |
| Thursday | Balanced lunch, check insurance coverage | Quinoa salad, confirm formulary status |
| Friday | Hydrate, monitor OSA symptoms | Drink tea, note breathing improvements |
| Saturday | Active outing, healthy dinner | Go hiking, eat salmon with veggies |
| Sunday | Prep for next shot, rest | Set reminder for Monday, do light yoga |
This table integrates Zepbound with lifestyle changes. It emphasizes consistency and medical follow-up.
Managing Side Effects
Zepbound may cause nausea, diarrhea, or fatigue. These can affect your treatment experience. Small, frequent meals can ease digestive issues.
Hydration helps reduce constipation or dizziness. Drink 8–10 cups of water daily. Avoid sugary drinks to prevent blood sugar spikes.
If side effects persist, contact your doctor. They may adjust your dose or suggest solutions. Don’t stop Zepbound without medical advice.
Combining Zepbound with Other Treatments
Zepbound is often used alongside CPAP for OSA. It doesn’t replace traditional treatments but complements them. Weight loss from Zepbound can reduce CPAP reliance over time.
Lifestyle changes, like a reduced-calorie diet, enhance Zepbound’s effects. Exercise, such as 150 minutes of walking weekly, supports weight loss. This improves OSA symptoms.
Discuss all treatments with your doctor. Combining therapies can maximize benefits. Ensure your plan aligns with Medicare coverage rules.
Potential Changes in Medicare Coverage
In November 2024, CMS proposed expanding coverage for weight loss drugs. If approved, this could allow Zepbound coverage for obesity starting in 2026. This would benefit more patients.
The proposal needs approval from the new administration. It could cost taxpayers billions, so it’s under review. Coverage for OSA remains the current standard.
Stay updated on policy changes. Contact Medicare or your insurer for the latest information. Future expansions could lower costs for Zepbound users.
Appealing a Coverage Denial
If Medicare denies Zepbound coverage, you can appeal. Review the denial notice for reasons, like missing documentation. Gather evidence, such as sleep study results or CPAP use records.
Your doctor can resubmit the prescription with the correct ICD-10 code (G47.33). Include details of failed treatments if required. Persistence often leads to approval.
Work with your insurer’s appeals process. Deadlines are strict, so act quickly. A successful appeal can secure coverage for Zepbound.
Tips for Success with Zepbound
Track your Zepbound doses and OSA symptoms in a journal. This helps monitor progress and side effects. Share this with your doctor during check-ins.
Work with a dietitian to create a reduced-calorie diet. This supports weight loss and OSA improvement. Nutrient-rich foods like vegetables are key.
Stay patient, as results take time. Regular follow-ups with your doctor ensure safe use. Consistency with Zepbound and lifestyle changes drives success.
Summary
Does Medicare cover Zepbound for sleep apnea? Yes, Medicare Part D and some Medicare Advantage plans cover it for moderate to severe OSA, not weight loss. You need a confirmed OSA diagnosis and a prescription for coverage. Costs vary, with copays up to $600 monthly and a $2,000 yearly cap. Follow steps like checking your plan’s formulary and securing prior authorization. Combine Zepbound with CPAP, diet, and exercise for best results, and appeal denials with proper documentation.
FAQ
Does Medicare cover Zepbound for sleep apnea?
Yes, Medicare Part D and some Part C plans cover Zepbound for moderate to severe OSA. It’s not covered for weight loss alone. Check your plan’s formulary.
What do I need for Medicare to cover Zepbound?
You need a diagnosis of moderate to severe OSA and a doctor’s prescription. A sleep study and proof of obesity may be required. Prior authorization might be needed.
How much does Zepbound cost with Medicare?
Copays range from $25 to $600 monthly, depending on your plan. The 2025 out-of-pocket cap is $2,000 yearly. Contact your insurer for exact costs.
What if Medicare denies Zepbound coverage?
Appeal the denial with sleep study results and treatment history. Your doctor can resubmit with the OSA diagnosis code. Act quickly to meet appeal deadlines.
Can I use Zepbound with CPAP for OSA?
Yes, Zepbound can complement CPAP therapy. It reduces weight, easing OSA symptoms. Discuss combining treatments with your doctor for best results.
Will Medicare cover Zepbound for weight loss in the future?
CMS proposed covering weight loss drugs like Zepbound in 2026. This needs approval and may increase access. For now, coverage is limited to OSA.

Dr. Hamza is a medical content reviewer with over 12+ years of experience in healthcare research and patient education. He specializes in evidence-based health information, medications, and chronic conditions. His reviews are grounded in trusted medical sources and current clinical guidelines to ensure accuracy, transparency, and reliability. Content reviewed by Dr. Hamza is intended for educational purposes and is not a substitute for professional medical advice.