Trulicity delivers dulaglutide through a convenient prefilled pen for once-weekly subcutaneous injections in adults with type 2 diabetes. This GLP-1 receptor agonist helps control blood sugar by enhancing insulin release, slowing gastric emptying, and reducing appetite. Many patients appreciate the straightforward design that simplifies self-administration at home.
While the pen generally works reliably, some users encounter occasional technical problems that prevent proper delivery of the medication. These issues range from failure to activate to incomplete dosing despite correct technique. Prompt recognition and handling keep treatment on track and minimize disruptions.
Understanding potential malfunctions empowers patients to respond calmly and seek appropriate support. Official instructions from Eli Lilly and FDA resources provide clear guidance. Always consult your healthcare provider or pharmacist when problems arise to ensure safe continued use.
How the Trulicity Pen Works
The Trulicity pen comes prefilled with a single weekly dose in strengths of 0.75 mg, 1.5 mg, 3 mg, or 4.5 mg per 0.5 mL. You remove the base cap, place it against clean skin, unlock if needed, and press the button to inject automatically. A click and visible plunger movement confirm delivery.
No priming step is required—unlike some other pens—which avoids common user errors. The needle hides automatically after use for safety. Each pen is single-use and disposable after injection.
Proper storage keeps the pen effective: refrigerate unopened boxes and allow room temperature for up to 14 days once removed. Never freeze or expose to extreme heat.
Common Signs of Trulicity Pen Malfunction
Users sometimes report the button failing to engage after placement on the skin. No click occurs, and the plunger stays stationary despite pressure. This leaves the full dose undelivered.
Other complaints include partial injection where only a small amount expels before stopping. The pen may feel jammed or resistant mid-dose. Rarely, multiple pens from the same box exhibit similar behavior.
These issues appear sporadically in user reports and FDA adverse event databases. They do not indicate widespread defects but warrant careful troubleshooting.
Trulicity Pen Malfunction: Step-by-Step Troubleshooting
Begin by confirming correct technique: remove the base cap only when ready, hold firmly against skin, unlock the pen, and press the button fully until the click sounds and plunger stops.
Check for visible damage like cracks or bent parts—discard if present and use a new pen. Ensure the pen reached room temperature if refrigerated, as cold medication can affect flow.
If the button resists, gently rock the pen slightly while pressing—never force excessively. Contact your pharmacy or Eli Lilly support immediately for replacements if the issue persists.
What to Do When the Pen Fails to Deliver
Stop attempting injection if nothing happens after proper steps. Note the lot number and expiration date for reporting. Use an alternative dose source if available to avoid missing your weekly schedule.
Contact your healthcare provider promptly to discuss options—perhaps a backup pen or temporary adjustment. Report the malfunction to Eli Lilly’s customer service line or through your pharmacist for potential free replacement.
Document the incident with photos if safe. This helps track patterns and supports any necessary follow-up with the manufacturer.
Comparison of Trulicity Pen Issues vs Similar Devices
Trulicity pens differ from some competitors in design, leading to unique troubleshooting needs. Here’s a comparison of common delivery problems across popular GLP-1 pens.
| Device | Common Malfunction | Frequency in Reports | Key Troubleshooting Tip | Manufacturer Response |
|---|---|---|---|---|
| Trulicity | Button fails to engage / no delivery | Moderate | Confirm no priming needed; hold firmly | Free replacements often provided |
| Ozempic | Dose selector stuck or partial dose | Low to moderate | Check cartridge alignment; rotate dial | Support line for replacements |
| Victoza | Needle clog or plunger resistance | Moderate | Prime as instructed; change needle | Needle exchange programs available |
| Bydureon BCise | Button lock failure | Low | Ensure full press; check expiration | Direct pharmacy coordination |
This table draws from user forums, FDA reports, and prescribing information. Individual experiences vary widely.
Preventing Future Pen Problems
Store pens properly to avoid temperature-related flow issues—refrigerate unopened and use within 14 days at room temperature. Handle gently to prevent physical damage during transport.
Follow exact instructions every time: no shaking, no priming, and full button press until click. Inspect each pen visually before use for leaks or irregularities.
Keep spares on hand if possible, especially during travel. Report recurring issues to your provider—they may switch strengths or devices if needed.
When to Contact Your Doctor or Pharmacist
Seek immediate help if a malfunction causes a missed dose and blood sugar rises significantly. Symptoms like high glucose signs warrant prompt medical advice.
For repeated failures from the same box, involve your pharmacy early—they often facilitate manufacturer replacements. Document symptoms and device details for accurate reporting.
Providers can assess if technique adjustments or alternative therapies better suit your needs. Consistent communication prevents treatment gaps.
Reporting Malfunctions Officially
Use the FDA MedWatch program online or by phone to report device issues formally. Include lot numbers, dates, and descriptions for investigation.
Contact Eli Lilly directly through their support line or website for potential replacements or credits. Pharmacies frequently handle initial claims efficiently.
Thorough reporting contributes to ongoing safety monitoring and potential improvements in device design.
Long-Term Management with Trulicity
Most users complete treatment courses without mechanical issues when following guidelines. Regular provider visits monitor efficacy and address any concerns early.
If device problems recur frequently, discuss switching to another GLP-1 option with your doctor. Alternatives like oral or different injectable forms exist.
Focus on overall diabetes management—diet, exercise, and monitoring complement medication for best control.
Summary
Trulicity pens occasionally experience malfunctions like failure to engage or incomplete delivery, often tied to technique, storage, or rare defects. Troubleshooting involves verifying steps, checking for damage, and contacting support promptly for replacements. No widespread recalls affect current supplies, but individual reports highlight the value of careful use.
Prompt action prevents missed doses and maintains glycemic control. Manufacturer and pharmacy resources provide reliable assistance. Open dialogue with healthcare teams ensures safe, effective treatment.
Prioritize proper handling and reporting to support your health journey. Reliable tools like Trulicity remain valuable when used correctly.
FAQ
What should I do if my Trulicity pen won’t inject?
Stop pressing and confirm you removed the base cap, held firmly against skin, and unlocked the pen. If still no delivery after proper technique, discard it safely and use a new pen if available. Contact your pharmacy or Eli Lilly for a replacement immediately.
Is there a known widespread Trulicity pen recall in 2026?
No active widespread recall exists for mechanical malfunctions in 2026 based on FDA and manufacturer data. Past minor recalls addressed labeling or other issues, not delivery failures. Report individual problems through official channels for monitoring.
Why might the Trulicity pen button not engage?
Common causes include incorrect cap removal, insufficient skin contact pressure, locked position, or cold medication affecting flow. Rarely, manufacturing defects occur in isolated cases. Follow step-by-step instructions precisely each time.
Can I prime a Trulicity pen if it seems jammed?
Never prime Trulicity pens—the design does not require or allow it. Attempting to force priming or extra steps risks damage. If jammed, contact support rather than attempting fixes yourself.
How do I report a Trulicity pen malfunction officially?
Submit details through FDA MedWatch online or by phone, including lot number and description. Also call Eli Lilly customer support directly—they often arrange replacements. Your pharmacist can assist with initial reporting and supply coordination.
Does a pen malfunction mean the medication is unsafe?
Mechanical issues typically affect delivery, not the drug safety itself. The dulaglutide remains stable if stored correctly. Focus on getting a working pen to resume dosing without gaps.
What alternatives exist if Trulicity pen problems continue?
Discuss switching to other GLP-1 options like Ozempic, Victoza, or oral Rybelsus with your provider. Different delivery systems may suit your needs better. Never stop treatment abruptly without medical guidance.
Dr. Hamza is a medical content reviewer with over 12+ years of experience in healthcare research and patient education. He specializes in evidence-based health information, medications, and chronic conditions. His reviews are grounded in trusted medical sources and current clinical guidelines to ensure accuracy, transparency, and reliability. Content reviewed by Dr. Hamza is intended for educational purposes and is not a substitute for professional medical advice.