Starting Wegovy can feel like a big step toward better health. This once-weekly injection, with semaglutide as its active ingredient, helps manage appetite and supports weight loss. If you’re curious about what lies ahead, you’re not alone.
The first week is often about adjusting to the medication. Your body needs time to get used to it, and side effects may pop up. Knowing what’s typical can ease your mind as you begin.
This article breaks down everything you need for a smooth start. From side effects to lifestyle tips, we’ll guide you through your first week on Wegovy. Let’s dive in and set you up for success.
Understanding Wegovy and Its Role in Weight Loss
Wegovy mimics a hormone called GLP-1, which signals fullness to your brain. This helps you eat less without feeling deprived. It’s FDA-approved for adults with obesity or weight-related health issues.
Results don’t happen overnight, but studies show up to 15% body weight loss over time. The first week starts with a low dose to ease you in. Pairing it with diet and exercise boosts effectiveness.
Your doctor will guide you on dosing and expectations. They’ll likely start you at 0.25 mg weekly for a month. This gradual approach minimizes discomfort while your body adjusts.
Preparing for Your First Wegovy Dose
Before your first shot, talk to your healthcare provider. They’ll confirm Wegovy suits your health goals and explain the injection process. You’ll get a pre-filled pen, designed for easy use.
Store the pen in the fridge until you’re ready. Let it warm to room temperature for 30 minutes before injecting. This makes the process more comfortable.
Check the pen’s liquid—it should be clear, not cloudy. Gather alcohol swabs and a sharps container. A clean, quiet space helps you focus for your first injection.
What Should I Expect the First Week of Wegovy: Common Experiences
Your first week on Wegovy is about starting small and noticing how your body reacts. Most people feel mild effects as the low dose begins working. Here’s what’s common and how to handle it.
Mild Nausea and Digestive Changes
Nausea is the most reported side effect early on. It’s usually mild and peaks a day or two after the shot. Eating smaller, bland meals can help settle your stomach.
Some experience bloating or slight diarrhea. These often fade as your body adjusts. Stay hydrated and avoid heavy, greasy foods to ease digestion.
If nausea feels overwhelming, rest and sip water or ginger tea. Contact your doctor if it lasts beyond a couple of days. They can offer tips or adjust your plan.
Reduced Appetite and Eating Habits
Wegovy starts curbing hunger within days. You might feel full faster or crave less food. This is the drug working to reset your appetite signals.
Use this to focus on nutrient-rich foods like vegetables and lean proteins. Avoid forcing large meals; listen to your body’s cues. Smaller portions align with Wegovy’s effects.
Keep a food journal to track changes. This helps you notice patterns and stay mindful. It’s a great tool for building healthier habits early on.
Possible Fatigue or Headaches
Some feel tired or get mild headaches in the first week. These often tie to lower calorie intake or dehydration. Rest and water can make a big difference.
Take it easy with exercise—light walks are enough for now. Overdoing it can worsen fatigue. Your energy should stabilize as you adapt.
If headaches persist, check your hydration and sleep. Over-the-counter pain relief can help, but check with your doctor first. They’ll rule out other causes.
Injection Site Reactions
You’ll inject Wegovy in your abdomen, thigh, or upper arm. The site might show mild redness or itching, which fades quickly. Proper technique prevents irritation.
Clean the area with an alcohol swab and rotate sites weekly. This keeps skin healthy and reduces discomfort. Ice the spot briefly if it stings.
Rarely, a small bump or bruise appears. These are normal but mention persistent issues to your doctor. They can check your injection method.
First Week Side Effects at a Glance
| Side Effect | Likelihood | Management Tips |
|---|---|---|
| Nausea | Common (50%+ of users) | Eat small, bland meals; sip ginger tea; rest. Contact doctor if severe or persistent. |
| Reduced Appetite | Very Common (70%+ of users) | Focus on nutrient-dense foods; use smaller plates; track intake to stay balanced. |
| Fatigue/Headaches | Moderate (20-30% of users) | Stay hydrated; rest adequately; avoid intense exercise. Consult doctor if ongoing. |
This table highlights what’s typical and how to cope. Most side effects are mild and improve with time. Always report severe symptoms to your doctor.
Tips for a Smooth First Week on Wegovy
Start with a consistent injection day, like Sunday morning. Set a reminder to stay on track. Timing doesn’t affect results, so pick what suits you.
Eat balanced meals with fiber to support digestion. Think veggies, whole grains, and lean proteins. Avoid sugary or fatty foods that might worsen nausea.
Stay active with light movement, like 20-minute walks. This boosts mood and energy without overtaxing your body. Rest when you feel tired.
Keep your doctor in the loop about any concerns. They can tweak your plan or offer reassurance. Support groups online can also share practical tips.
Building Healthy Habits Alongside Wegovy
Wegovy works best with lifestyle changes. Use the first week to plan meals that align with your goals. Prep simple recipes to avoid takeout temptations.
Aim for 7-8 hours of sleep nightly. Poor sleep can increase hunger, countering Wegovy’s effects. A bedtime routine helps you wind down.
Track your progress with a journal or app. Note weight, energy, and mood, not just numbers. Small wins, like better focus, add up fast.
Join a community, like a fitness group or online forum. Sharing experiences keeps you motivated. Celebrate milestones, no matter how small.
When to Contact Your Healthcare Provider
Mild side effects are normal, but some need attention. Severe nausea, vomiting, or dizziness should prompt a call. Don’t wait if symptoms disrupt your day.
Allergic reactions, like swelling or rash, are rare but serious. Stop the injection and seek help immediately. Quick action keeps you safe.
If you miss a dose within five days, take it as soon as possible. Beyond that, skip it and resume your schedule. Never double up without guidance.
Discuss any new symptoms, like vision changes or heart palpitations. Your doctor can assess if they’re linked to Wegovy. Regular check-ins ensure safety.
Long-Term Expectations Beyond the First Week
The first week sets the stage, but Wegovy’s benefits grow over time. Your dose will increase gradually, often every four weeks. This builds tolerance and effectiveness.
Weight loss may start slowly, with 1-2 pounds in the first month. By week 12, many see steadier results. Consistency with diet and exercise is crucial.
Side effects often lessen after the first month. Your body adapts, and nausea typically fades. Keep tracking to spot patterns and stay proactive.
Stay in touch with your healthcare team for dose adjustments. They’ll monitor your progress and health markers. Blood sugar or cholesterol may improve too.
Summary
The first week of Wegovy brings mild side effects like nausea, reduced appetite, and possible fatigue. Injecting correctly and eating balanced meals ease the transition. Track changes and stay in touch with your doctor for guidance.
With light exercise and good sleep, you’ll build habits that amplify Wegovy’s effects. Patience is key—results grow over months. You’re laying the foundation for lasting health.
FAQ
Is nausea normal in the first week of Wegovy?
Yes, mild nausea is common and peaks 1-2 days after the shot. Eat small, bland meals and stay hydrated. Call your doctor if it’s severe or doesn’t improve.
Can I exercise during my first week on Wegovy?
Light exercise, like walking, is fine and boosts energy. Avoid intense workouts if you feel tired or nauseous. Listen to your body and rest as needed.
What if I miss my Wegovy dose in the first week?
Take it within five days if possible; otherwise, skip and resume your schedule. Don’t double the dose. Check with your doctor for specific advice.
How soon will I see weight loss with Wegovy?
Weight loss may start within weeks but is often slow initially. Expect 1-2 pounds in the first month with diet and exercise. Results accelerate over time.
Should I change my diet in the first week of Wegovy?
Focus on nutrient-rich foods like vegetables and lean proteins. Avoid heavy or sugary meals to reduce nausea. A food journal helps track new habits.
Dr. Hamza is a medical content reviewer with over 12+ years of experience in healthcare research and patient education. He specializes in evidence-based health information, medications, and chronic conditions. His reviews are grounded in trusted medical sources and current clinical guidelines to ensure accuracy, transparency, and reliability. Content reviewed by Dr. Hamza is intended for educational purposes and is not a substitute for professional medical advice.